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Methylation of p53 protein by KMT7/SET7 is the primary reported KMT-mediated methylation event on a non-histone protein 18 Since that discovery, a number of KMTs, in addition to KDM1A, have been identified as p53 regulators that methylate or demethylate p53 protein, making p53 the most extensively studied non-histone protein undergoing lysine methylation 4 , thirteen , 16 , 18 , 162 Here we use p53 as a model to discuss the features of lysine methylation of non-histone proteins.